Experimental study and first clinical results with a cooled applicator system for LITT

Verena Knappe; Andre Roggan; Martin G. Mack; Thomas J. Vogl; Dirk Albrecht; Christoph-Thomas Germer; F. Kniep; Gerhard J. Mueller

doi:10.1117/12.300822

19 January 1998 Experimental study and first clinical results with a cooled applicator system for LITT

Verena Knappe, Andre Roggan, Martin G. Mack, Thomas J. Vogl, Dirk Albrecht, Christoph-Thomas Germer, F. Kniep, Gerhard J. Mueller

Author Affiliations +

Proceedings Volume 3193, Photothermal Therapies in Medicine; (1998) https://doi.org/10.1117/12.300822
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

Laser-induced interstitial thermotherapy has proven to be an effective method for the treatment of different types of tumors. Until now the attainable coagulation volume was limited by the maximum applicable energy. The limiting factor is the high tissue temperatures around the applicator which may cause applicator damage. Consequently an internally cooled catheter system has been developed in order to reduce the temperature of the applicator surface and therefore enable the application of higher laser powers. The optimal treatment parameters for the Nd:YAG laser were determined on the basis of computer simulations and in vitro studies with porcine liver. Following these experimental studies, 72 patients with liver metastases were treated with the cooled applicator system. The applicator position and the resulting tissue damage were verified using the MRI on- line monitoring system with a FLASH-2D sequence. The optimal treatment parameters were found to be 25 watts for an exposure time of 20 minutes, resulting in coagulated volumes of up to 20 cm³. The experimental and clinical results proved that the combination of a scattering laser applicator with an internally flushed catheter enables a significant increase in the coagulation volume.

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Verena Knappe, Andre Roggan, Martin G. Mack, Thomas J. Vogl, Dirk Albrecht, Christoph-Thomas Germer, F. Kniep, and Gerhard J. Mueller "Experimental study and first clinical results with a cooled applicator system for LITT", Proc. SPIE 3193, Photothermal Therapies in Medicine, (19 January 1998); https://doi.org/10.1117/12.300822

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