Improved SPECT reconstruction of Tc-99m sestamibi distribution in breast tissue

Andrzej Krol; David H. Feiglin; George M. Gagne; Walter Huda; Gwen M. Tillapough-Fay; Bradford J. Hellwig; Deaver F. Thomas

doi:10.1117/12.310923

24 June 1998 Improved SPECT reconstruction of Tc-99m sestamibi distribution in breast tissue

Andrzej Krol, David H. Feiglin, George M. Gagne, Walter Huda, Gwen M. Tillapough-Fay, Bradford J. Hellwig, Deaver F. Thomas

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Proceedings Volume 3338, Medical Imaging 1998: Image Processing; (1998) https://doi.org/10.1117/12.310923
Event: Medical Imaging '98, 1998, San Diego, CA, United States

Abstract

This paper describes a new image reconstruction method to reduce the presence of image artifacts in scintimammography. SPECT data are mathematically modified prior to conventional image processing, followed by an inverse transform, which permits the tomographic visualization of low signals in the presence of large background intensities observed in scintimammography. Images of Tc-99m sestamibi distribution were obtained in a modeled `breast tissue', with a high activity in the `myocardium' as compared to the `breast tissue' (i.e. 20:1). Image reconstruction with the modified algorithm were qualitatively correct and demonstrated the regions of enhanced uptake (lesions) with no evidence of artifacts from the background counts in the heart. Comparison with MRI demonstrated that the hot regions were properly located and correlated with the MRI data. In contrast, a standard (i.e. Filtered Back Projection) reconstruction resulted in streak artifacts in place of `breast tissue' which rendered them clinically useless. This new approach to scintimammography offers the prospect of significantly reducing image artifacts and improving imaging accuracy.

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Andrzej Krol, David H. Feiglin, George M. Gagne, Walter Huda, Gwen M. Tillapough-Fay, Bradford J. Hellwig, and Deaver F. Thomas "Improved SPECT reconstruction of Tc-99m sestamibi distribution in breast tissue", Proc. SPIE 3338, Medical Imaging 1998: Image Processing, (24 June 1998); https://doi.org/10.1117/12.310923

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KEYWORDS

Breast

Tissues

Single photon emission computed tomography

Reconstruction algorithms

Magnetic resonance imaging

Heart

Image processing

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