Ultrasound interstitial thermal therapy (USITT) in the prostate

William H. Nau; Chris J. Diederich; Dana L. Deardorff

doi:10.1117/12.348745

19 May 1999 Ultrasound interstitial thermal therapy (USITT) in the prostate

William H. Nau, Chris J. Diederich, Dana L. Deardorff

Proceedings Volume 3594, Thermal Treatment of Tissue with Image Guidance; (1999) https://doi.org/10.1117/12.348745
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

This research represents an experimental investigation of the use of interstitial catheter-cooled ultrasound applicators in various treatment strategies for the management of localized prostate cancer and benign prostatic hyperplasia. The anticipated clinical approaches under consideration were: (1) Ultrasound Interstitial Thermal therapy (USITT) alone for treatment of the whole gland, (2) high dose rate (HDR) brachytherapy with USITT to treat local recurrences or extracapsular extensions of the disease, and (3) sequence HDR brachytherapy and hyperthermia. Directional multielement catheter-cooled ultrasound applicators were fabricated using cylindrical piezoceramic transducers which can be inserted into 13 or 14 gage catheters. The applicators were characterized through measurements of acoustic power output, and beam profile distributions in degassed water. Thermal lesion formation studies were performed in an in vitro setup using fresh beef muscle. Various implant strategies were evaluated for the ability to control the temperature distribution within a pre-determined volume of tissue. Lesions extending more than 15 mm from the applicator surface were generated within 5 minutes of heating. Preliminary results from this study demonstrate the versatility of catheter-cooled interstitial ultrasound applicators, and their potential to provide controlled thermal therapy in the prostate.

Citation Download Citation

William H. Nau, Chris J. Diederich, and Dana L. Deardorff "Ultrasound interstitial thermal therapy (USITT) in the prostate", Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); https://doi.org/10.1117/12.348745

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