Constructing biomolecular motor-powered hybrid NEMS devices

George D. Bachand; Carlo D. Montemagno

doi:10.1117/12.364481

1 October 1999 Constructing biomolecular motor-powered hybrid NEMS devices

George D. Bachand, Carlo D. Montemagno

Proceedings Volume 3892, Device and Process Technologies for MEMS and Microelectronics; (1999) https://doi.org/10.1117/12.364481
Event: Asia Pacific Symposium on Microelectronics and MEMS, 1999, Gold Coast, Australia

Abstract

The recognition of many enzymes as nanoscale molecular motors has allowed for the potential creation of hybrid organic/inorganic nano-electro-mechanical (NEMS) devices. The long-range goal of this research is the integration of F₁-ATPase with NEMS to produce useful nanoscale devices. A thermostable F₁-ATPase coding sequence has been isolated, cloned, and engineered for high-level protein expression. Precise positioning, spacing, and orientation of single F₁-ATPase molecules were achieved using patterned nickel arrays. An efficient, accurate, and adaptable assay was developed to assess the performance of single F₁- ATPase motors, and confirmed a three-step mechanism of (gamma) subunit rotation during ATP hydrolysis. Further evaluation of the bioengineering and biophysical properties of F₁-ATPase currently are being conducted, as well as the construction of an F₁-ATPase-powered, hybrid NEMS device. The evolution of this technology will permit the creation of novel classes of nanoscale, hybrid devices.

Citation Download Citation

George D. Bachand and Carlo D. Montemagno "Constructing biomolecular motor-powered hybrid NEMS devices", Proc. SPIE 3892, Device and Process Technologies for MEMS and Microelectronics, (1 October 1999); https://doi.org/10.1117/12.364481

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