Mechanisms for protein micro-/nano-patterning on photopolymer substrates

Dan V. Nicolau

doi:10.1117/12.379568

15 March 2000 Mechanisms for protein micro-/nano-patterning on photopolymer substrates

Dan V. Nicolau

Proceedings Volume 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications; (2000) https://doi.org/10.1117/12.379568
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Two mechanisms can be applied initially for the high resolution patterning on radiation-assisted functionalized polymer surfaces: hydrophobicity-controlled patterning; and chemical linkage. The present contribution assesses the merits and drawbacks of these mechanisms in terms of resolution and contrast of protein/peptide features. Two microlithographic materials (an acrylate-based system and a diazo-naphto-quinone one); and two lithographic methods (e-beam and optical) have been used to test the merits of the protein patterning mechanisms. The hydrophobicity-controlled patterning produces sharp images but with multiple defects, whereas chemical linkage produces defect-free images but with a decreased contrast. The benefits of a third mechanism for protein confinement, namely bimolecular specific recognition, was explored in the view of the possible fabrication of artificial molecular motors.

Citation Download Citation

Dan V. Nicolau "Mechanisms for protein micro-/nano-patterning on photopolymer substrates", Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); https://doi.org/10.1117/12.379568

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