Comparison of near-infrared spectroscopy with CT cerebral blood flow measurements in newborn piglets

Derek W. Brown; Paul A. Picot; Roger Springett; David T. Delpy; Ting-Yim Lee

doi:10.1117/12.428134

21 May 2001 Comparison of near-infrared spectroscopy with CT cerebral blood flow measurements in newborn piglets

Derek W. Brown, Paul A. Picot, Roger Springett, David T. Delpy, Ting-Yim Lee

Proceedings Volume 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images; (2001) https://doi.org/10.1117/12.428134
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

Severely premature infants are often at high risk of cerebral hemorrhage or ischemic injury due to their inability to properly regulate blood flow to the brain. If blood flow is too high, the infant is at risk of cerebral hemorrhage, while too little blood flow can result in ischemic injury. The purpose of this research is to design and develop a means of non-invasively measuring cerebral blood flow (CBF) with near infrared spectroscopy (NIRS). Such a device would greatly aid the diagnosis and monitoring of afflicted infants. Previous attempts to measure CBF with NIRS have achieved limited success. In this study we acquired high signal-to-noise NIR spectrum from 600 to 980 nm with a cooled CCD spectrometer. This spectrometer enables the differential path length factor (DPF) to be estimated with accuracy using a second derivative technique described by Matcher et al. The validity of our new approach is determined via direct comparison with a previously validated computed tomography (CT) method. Three newborn piglets were studied. CBF measurements were performed at various partial arterial CO₂ tensions (PaCO₂) using both the NIRS and CT methods. The results of the two methods correlate well with a relationship of CBF_CT equals -4.30 + 1.05 CBF_NIRS (r² equals 0.96).

Citation Download Citation

Derek W. Brown, Paul A. Picot, Roger Springett, David T. Delpy, and Ting-Yim Lee "Comparison of near-infrared spectroscopy with CT cerebral blood flow measurements in newborn piglets", Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); https://doi.org/10.1117/12.428134

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