X-ray measurement of regional blood flow distribution using radiopaque contrast medium: influence of gravity

Anne V. Clough; Steven T. Haworth; David T. Roerig; Christopher C. Hanger; Christopher A. Dawson

doi:10.1117/12.428149

21 May 2001 X-ray measurement of regional blood flow distribution using radiopaque contrast medium: influence of gravity

Anne V. Clough, Steven T. Haworth, David T. Roerig, Christopher C. Hanger, Christopher A. Dawson

Author Affiliations +

Proceedings Volume 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images; (2001) https://doi.org/10.1117/12.428149
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

X-ray CT measurement of regional blood flow distribution in the lungs is potentially biased because the contrast medium used to track the flow is denser than blood. To evaluate this gravity effect, cross-sectionally uniform boluses (Reno 60, density 1.3) were delivered at the upstream end of a horizontal tube connected to a downstream axisymmetric bifurcation. When the plane of the bifurcation was vertical and actual flow through the two branches was equal, the fraction of contrast medium passing through the downward- directed branch increased with decreasing Reynolds number, increasing length-to-diameter ratio of the horizontal tube, and decreasing bolus volume. In the lungs, Reynolds number decreases and pathway length increases with decreasing vessel diameter. Thus, the results suggest that the spatial resolution of CT flow measurement within the lungs may be limited by density differences between contrast medium and blood.

Citation Download Citation

Anne V. Clough, Steven T. Haworth, David T. Roerig, Christopher C. Hanger, and Christopher A. Dawson "X-ray measurement of regional blood flow distribution using radiopaque contrast medium: influence of gravity", Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); https://doi.org/10.1117/12.428149

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