Speckle diagnostics and biomicroscopy of lymph flow in microvessels

Ekateryna I. Galanzha; Anastasiya V. Solov'eva; Sergey S. Ulyanov; Valery V. Tuchin; Gregory E. Brill

doi:10.1117/12.438416

22 August 2001 Speckle diagnostics and biomicroscopy of lymph flow in microvessels

Ekateryna I. Galanzha, Anastasiya V. Solov'eva, Sergey S. Ulyanov, Valery V. Tuchin, Gregory E. Brill

Proceedings Volume 4427, Imaging of Tissue Structure and Function; (2001) https://doi.org/10.1117/12.438416
Event: Imaging of Tissue Structure and Function, 2001, none, Russian Federation

Abstract

In the present study speckle-interferometry and TV intravital biomicroscopy techniques has been proposed for the analysis of microcirculatory parameters. The power spectra of fluctuation of intensity, scattered by these vessels, have a complicated shape. The mean value of first spectral movement M₁ (which is assumed to be directly proportional to average velocity) in lymphatics with spontaneous contractions differ from vessels without phasic activity. We register two types of histogram of M₁ in contracting and non-contracting vessels. The phasic contractions may be caused by the modification of lymph flow in microvessels and/or by the changes of the speckle signal values. An application of lymphotropic drugs (staphylococcal toxin, N-nitro-L-arginine and dimethyl sufoxide) on the lymph microvessels has been investigated. The study of lymph flow by two methods (intravital TV biomicroscopy and speckle-interferometry) allows to determine the ways of the action of vasoactive drugs on lymph flow.

Citation Download Citation

Ekateryna I. Galanzha, Anastasiya V. Solov'eva, Sergey S. Ulyanov, Valery V. Tuchin, and Gregory E. Brill "Speckle diagnostics and biomicroscopy of lymph flow in microvessels", Proc. SPIE 4427, Imaging of Tissue Structure and Function, (22 August 2001); https://doi.org/10.1117/12.438416

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