Hyperspectral imaging technology for pharmaceutical analysis

Sara J. Hamilton; Robert A. Lodder

doi:10.1117/12.472076

21 June 2002 Hyperspectral imaging technology for pharmaceutical analysis

Sara J. Hamilton, Robert A. Lodder

Proceedings Volume 4626, Biomedical Nanotechnology Architectures and Applications; (2002) https://doi.org/10.1117/12.472076
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The sensitivity and spatial resolution of hyperspectral imaging instruments are tested in this paper using pharmaceutical applications. The first experiment tested the hypothesis that a near-IR tunable diode-based remote sensing system is capable of monitoring degradation of hard gelatin capsules at a relatively long distance. Spectra from the capsules were used to differentiate among capsules exposed to an atmosphere containing imaging spectrometry of tablets permits the identification and composition of multiple individual tables to be determined simultaneously. A near-IR camera was used to collect thousands of spectra simultaneously from a field of blister-packaged tablets. The number of tablets that a typical near-IR camera can currently analyze simultaneously form a field of blister- packaged tablets. The number of tablets that a typical near- IR camera can currently analyze simultaneously was estimated to be approximately 1300. The bootstrap error-adjusted single-sample technique chemometric-imaging algorithm was used to draw probability-density contour plots that revealed tablet composition. The single-capsule analysis provides an indication of how far apart the sample and instrumentation can be and still maintain adequate S/N, while the multiple- sample imaging experiment gives an indication of how many samples can be analyzed simultaneously while maintaining an adequate S/N and pixel coverage on each sample.

Citation Download Citation

Sara J. Hamilton and Robert A. Lodder "Hyperspectral imaging technology for pharmaceutical analysis", Proc. SPIE 4626, Biomedical Nanotechnology Architectures and Applications, (21 June 2002); https://doi.org/10.1117/12.472076

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