Monitoring the growth of tumors in the liver using dynamic CT

Errol E. Stewart; Xiaogang Chen; Jennifer Hadway; Ting-Yim Lee

doi:10.1117/12.480419

2 May 2003 Monitoring the growth of tumors in the liver using dynamic CT

Errol E. Stewart, Xiaogang Chen, Jennifer Hadway, Ting-Yim Lee

Proceedings Volume 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications; (2003) https://doi.org/10.1117/12.480419
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Conventional CT imaging methods lack the accuracy that is necessary for detailed assessment of liver metastasis. However, quantitative measurement of hepatic perfusion has the potential to provide important information necessary for both the evaluation and treatment of liver metastasis. VX2 carcinoma cells were injected into the liver of healthy male rabbits. A two-phase scan protocol was used to acquire CT images for the determination of liver perfusion prior to and post implantation. Contrast enhancement curves from the aorta, portal vein and liver parenchyma were obtained from the reconstructed images. The weighted summation of the aortic and portal venous curve were de-convolved against the liver parenchymal curve to derive functional parameters such as total hepatic blood flow (HBF) and hepatic arterial fraction (HAF). Results show that the HAF of the implanted tumor increased throughout the period of the study. Twelve days after tumors were implanted the HAF in the liver significantly increased (P < 0.05) from the normal tissue value of 35 ± 1 to 57 ± 9 %. Functional maps of the HAF have the potential to improve treatment outcome of patients owing to the earlier diagnosis of liver cancer. We are able to detect VX2 tumors in the liver as early as 8 days after they were implanted.

Citation Download Citation

Errol E. Stewart, Xiaogang Chen, Jennifer Hadway, and Ting-Yim Lee "Monitoring the growth of tumors in the liver using dynamic CT", Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); https://doi.org/10.1117/12.480419

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available