Microscopic evaluation of femtosecond laser intrastromal surgery

Meng Han; Leander Zickler; Matthias Walter; Guenter Giese; Frieder Loesel; Josef F. Bille

doi:10.1117/12.500267

16 October 2003 Microscopic evaluation of femtosecond laser intrastromal surgery

Meng Han, Leander Zickler, Matthias Walter, Guenter Giese, Frieder Loesel, Josef F. Bille

Proceedings Volume 5142, Therapeutic Laser Applications and Laser-Tissue Interactions; (2003) https://doi.org/10.1117/12.500267
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Diode pumped Nd:glass all-solid-state femtosecond laser is promising for next generation refractive surgery, with the advantages of excellent surgical precision, minimal tissue damage and improved system stability and compactness. The microscopic evaluation of the outcome of femtosecond laser surgery is crucial before clinical applications. By two-photon laser scanning microscopy and non-invasive second harmonic imaging, the three dimensional ultrastructure of the porcine cornea is visualized without requiring slicing or staining. The minimal-invasive corneal flap cutting and non-invasive intrastromal surgery are investigated. Femtosecond laser intrastromal surgery demonstrated high ablation precision and mimimal side effects. However, there are elongated filaments/streaks observed in the cornea stroma, most likely due to the focusing optics and self-focusing.

Citation Download Citation

Meng Han, Leander Zickler, Matthias Walter, Guenter Giese, Frieder Loesel, and Josef F. Bille "Microscopic evaluation of femtosecond laser intrastromal surgery", Proc. SPIE 5142, Therapeutic Laser Applications and Laser-Tissue Interactions, (16 October 2003); https://doi.org/10.1117/12.500267

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