Role of Toll-like receptors in photodynamic-therapy-elicited host response

Mladen Korbelik

doi:10.1117/12.529783

1 July 2004 Role of Toll-like receptors in photodynamic-therapy-elicited host response

Mladen Korbelik

Proceedings Volume 5319, Laser Interaction with Tissue and Cells XV; (2004) https://doi.org/10.1117/12.529783
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Treatment of solid tumors by photodynamic therapy (PDT) induces a host reaction, coordinated through a network of inflammatory and immune responses, that plays an important role in the therapy outcome. It is suggested that this host response is initiated by altered self-associated endogenous danger signals massively released from PDT-treated tumors. Toll-like receptors, localized predominantly in the membrane of immune cells, are the major sensors of the recognition arm of the innate immune system. The engagement of these receptors by PDT-generated danger signals prompts the activation of the networks of innate immunity signaling pathways leading to the downstream activation of nuclear transcription factors responsible for the transcription of inflammatory/immune response-associated genes. The contribution of PDT-induced host response to the therapeutic outcome depends on the balance between the tissue-destructive action of inflammatory/immune effectors and the impact of concomitantly mobilized negative regulatory mechanisms evolved for controlling the intensity and duration of inflammatory and immune responses.

Citation Download Citation

Mladen Korbelik "Role of Toll-like receptors in photodynamic-therapy-elicited host response", Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); https://doi.org/10.1117/12.529783

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