Two-photon absorption-induced drug delivery from polymers for medical applications

Hee-Cheol Kim; Stefan Kreiling; Sebastian Haertner; Lutz Hesse; Andreas Greiner; Norbert A. Hampp

doi:10.1117/12.523588

21 June 2004 Two-photon absorption-induced drug delivery from polymers for medical applications

Hee-Cheol Kim, Stefan Kreiling, Sebastian Haertner, Lutz Hesse, Andreas Greiner, Norbert A. Hampp

Proceedings Volume 5323, Multiphoton Microscopy in the Biomedical Sciences IV; (2004) https://doi.org/10.1117/12.523588
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Novel polymeric materials carrying a drug depot have been developed which are suitable for fabrication of photochemically modulated drug delivery devices. In order to avoid uncontrolled drug release the drug is covalently attached to the polymer backbone using a photo-active linker. Controlled drug release from the polymer can be accomplished either via single-photon excitation or by two-photon absorption (TPA). In particular the second possibility is of interest for applications where exposure to day light or UV light may not be omitted. One example are polymeric intraocular lenses (IOL), which are implanted instead of the opaque natural lens during cataract surgery. Secondary cataract formation is quite often observed after implantation of polymeric IOLs. In this study the well known cell toxic agent 5-fluorouracil (5FU) attached to a methylmethacrylate-based polymer was investigated as an IOL which can upon photochemical excitation release 5FU in order to treat or to prevent secondary cataract formation. The photochemical cleavage of the linker molecule was analyzed with single- and two-photon excitation. UV/VIS spectroscopy and HPLC analysis confirmed the release of 5FU form the polymer backbone. The diffusion of the drug precursor out from the polymer as well as the hydrolysis of the drug precursor which leads to 5FU formation were investigated in vitro.

Citation Download Citation

Hee-Cheol Kim, Stefan Kreiling, Sebastian Haertner, Lutz Hesse, Andreas Greiner, and Norbert A. Hampp "Two-photon absorption-induced drug delivery from polymers for medical applications", Proc. SPIE 5323, Multiphoton Microscopy in the Biomedical Sciences IV, (21 June 2004); https://doi.org/10.1117/12.523588

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