Glucose micro- and nano-sensors based on nanoassembled enzyme/polymer/dye composites

J. Quincy Brown; Suruchi Chopra; Patrick S. Grant; Michael J. McShane

doi:10.1117/12.529797

18 June 2004 Glucose micro- and nanosensors based on nanoassembled enzyme/polymer/dye composites

J. Quincy Brown, Suruchi Chopra, Patrick S. Grant, Michael J. McShane

Proceedings Volume 5325, Optical Diagnostics and Sensing IV; (2004) https://doi.org/10.1117/12.529797
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Minimally-invasive glucose sensors are attractive for disease management as well as medical and biological research applications. Fluorescent sensors, coupling enzymes to catalyze specific reactions with glucose, have been developed for this purpose. Our work has focused on the downscaling of these technologies to the micro- and nano-scale by using self-assembly to build the sensing components of the assays. Both "solid" polymers and hollow microshells have been developed to physically couple the sensing materials together in biocompatible, semipermeable packages suitable for use in biological systems. Fabrication details and sensor characterization are used to demonstrate the potential of these sensor concepts.

Citation Download Citation

J. Quincy Brown, Suruchi Chopra, Patrick S. Grant, and Michael J. McShane "Glucose micro- and nanosensors based on nanoassembled enzyme/polymer/dye composites", Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); https://doi.org/10.1117/12.529797

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