Noncontact subnanometer measurement of transient surface displacement during action potential propagation

Taner Akkin; Digant P. Dave; H. Grady Rylander III; Thomas E. Milner

doi:10.1117/12.592026

13 April 2005 Noncontact subnanometer measurement of transient surface displacement during action potential propagation

Taner Akkin, Digant P. Dave, H. Grady Rylander III, Thomas E. Milner

Proceedings Volume 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX; (2005) https://doi.org/10.1117/12.592026
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We have demonstrated non-contact, sub-nanometer optical measurement of neural surface displacement associated with action potential propagation without applying exogenous chemicals or reflection coatings. Signals recorded from crayfish leg nerve using a phase-sensitive optical low coherence reflectometer show that transient neural surface displacement due to action potential propagation is approximately 1 nm in amplitude and 1 ms in duration. Measured optical signals are coincident with electrical action potential arrival to the optical measurement site. Recent experiments indicate signals with similar amplitude and duration are observed in response to repetitive fast stimulation (200 stimuli/s).

Citation Download Citation

Taner Akkin, Digant P. Dave, H. Grady Rylander III, and Thomas E. Milner "Noncontact subnanometer measurement of transient surface displacement during action potential propagation", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); https://doi.org/10.1117/12.592026

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