Power and prospects for studying live cells using semiconductor quantum dots

Daniele Gerion

doi:10.1117/12.591246

4 April 2005 Power and prospects for studying live cells using semiconductor quantum dots

Daniele Gerion

Proceedings Volume 5704, Genetically Engineered and Optical Probes for Biomedical Applications III; (2005) https://doi.org/10.1117/12.591246
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

The use of quantum dots to study and solve biological issues is bringing scientists and engineers into the realm of pure biology. Yet quantum dots are still a young technology that has not fulfilled all its immense promises. The prospects of using quantum dots in biology motivates a wealth of different studies that include the targeting of organisms in live cells and the characterization of the optical properties of the bioconjugates at the single molecule level. Here, I want to review some experiments using silanized quantum dots. In particular, I want to focus on the versatility of silanized quantum dots for bioconjugation and show how they can be programmed to target the nucleus of live cells. In parallel, silanized qdots are remarkable chromophores that can be used as FRET sensors. FRET efficiencies up to 100% can be reached by tuning the spectral properties of the donor and acceptor pairs.

Citation Download Citation

Daniele Gerion "Power and prospects for studying live cells using semiconductor quantum dots", Proc. SPIE 5704, Genetically Engineered and Optical Probes for Biomedical Applications III, (4 April 2005); https://doi.org/10.1117/12.591246

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