Volumetric analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner

M. Waleed Gaber; Christy M. Wilson; Christopher D. Duntsch; Hemant Shukla; Janice A. Zawaski; Lawrence M. Jordan; David A. Rendon; Sravanthi Vangalaa; Gary S. Keyes; Frank A. DiBianca

doi:10.1117/12.595786

14 April 2005 Volumetric analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner

M. Waleed Gaber, Christy M. Wilson, Christopher D. Duntsch, Hemant Shukla, Janice A. Zawaski, Lawrence M. Jordan, David A. Rendon, Sravanthi Vangalaa, Gary S. Keyes, Frank A. DiBianca

Author Affiliations +

Proceedings Volume 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images; (2005) https://doi.org/10.1117/12.595786
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

The Variable Resolution X-ray (VRX) CT system, developed at the UTHSC, Memphis, has the potential for use in animal imaging. Animal models of tumor progression and pharmacological impact are becoming increasingly important in understanding the molecular and mechanistic basis of tumor development. In general, CT-imaging offers several advantages in animal research: a fast throughput of seconds to minutes reducing the physiological stress animals are exposed to, and it is an inexpensive modality affordable to many animal laboratories. We are developing the VRX CT scanner as a non-invasive imaging modality to measure tumor volume, progression, and metastasis. From the axial images taken by the VRX CT-scanner, tumor area was measured and the tumor volume was calculated. Animals were also imaged using an optical liquid nitrogen-cooled CCD camera to detect tumor fluorescence. A simple image fusion with a planner x-ray image was used to ascertain the position of the tumors, animals were then sacrificed the tumors excised, and the tumor volume calculated by physical measurements. Furthermore, using a specially designed phantom with three spheres of different volumes, we demonstrated that our system allowed us to estimate the volume with up to 10% accuracy; we expect this to increase dramatically in the next few months.

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M. Waleed Gaber, Christy M. Wilson, Christopher D. Duntsch, Hemant Shukla, Janice A. Zawaski, Lawrence M. Jordan, David A. Rendon, Sravanthi Vangalaa, Gary S. Keyes, and Frank A. DiBianca "Volumetric analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner", Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); https://doi.org/10.1117/12.595786

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KEYWORDS

Tumors

X-rays

Optical spheres

Brain

X-ray computed tomography

X-ray imaging

Imaging systems

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