Short-pulse laser propagation through tissue medium for tumor detection

Gopalendu Pal; Kunal Mitra; Tuan Vo-Dinh

doi:10.1117/12.664121

25 February 2006 Short-pulse laser propagation through tissue medium for tumor detection

Gopalendu Pal, Kunal Mitra, Tuan Vo-Dinh

Proceedings Volume 6080, Advanced Biomedical and Clinical Diagnostic Systems IV; 608005 (2006) https://doi.org/10.1117/12.664121
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The objective of this paper is to perform a comprehensive experimental and numerical analysis of the short pulse laser interaction with tissue medium with the goal of tumor / cancer diagnostics. For short pulse laser source, the shape of output signal is a function of the optical properties of the medium and hence the scattered temporal optical signal helps in understanding of the medium characteristics. Initially experiments are performed on tissue phantoms imbedded with inhomogeneities in order to optimize the time-resolved optical detection scheme. Both the temporal and the spatial profiles of the scattered reflected and transmitted optical signals are compared with the numerical modeling results obtained by solving the transient radiative transport equation using the discrete ordinates technique. Next experiments are performed on in vitro rat tissue samples to characterize the interaction of light with skin layers and to validate the time varying optical signatures with the numerical model. The numerical modeling results and the experimental measurements are in excellent agreement for the different parameters studied in this paper. The final step is to perform in vivo imaging of anaesthetized rats with tumor-promoting agents injected inside skin tissues in order to demonstrate the feasibility of the technique in detecting tumors in animal model.

Citation Download Citation

Gopalendu Pal, Kunal Mitra, and Tuan Vo-Dinh "Short-pulse laser propagation through tissue medium for tumor detection", Proc. SPIE 6080, Advanced Biomedical and Clinical Diagnostic Systems IV, 608005 (25 February 2006); https://doi.org/10.1117/12.664121

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KEYWORDS

Tissue optics

Tumors

Skin

Tissues

Photons

Numerical modeling

Scattering

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