Steroids block the anti-inflammatory effects of low level laser therapy

Rodrigo Alvaro Brandao Lopes-Martins; Regiane Albertini; Patricia Sardinha Leonardo Lopes-Martins; Vegard Vereide Iversen; Jan Magnus Bjordal

doi:10.1117/12.645468

28 February 2006 Steroids block the anti-inflammatory effects of low level laser therapy

Rodrigo Alvaro Brandao Lopes-Martins, Regiane Albertini, Patricia Sardinha Leonardo Lopes-Martins, Vegard Vereide Iversen, Jan Magnus Bjordal

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Proceedings Volume 6140, Mechanisms for Low-Light Therapy; 61400D (2006) https://doi.org/10.1117/12.645468
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Objective: Concomitant use of multiple therapies is common in musculoskeletal and airway disorders. Low level laser therapy (LLLT) is considered a promising therapy in arthritis, tendinopathies and rhinitis. We designed two animal studies to assess if the expected anti-inflammatory effect LLLT could be affected by resection of the adrenal gland or concomitant use of the cortisol antagonist mifepristone. Methods: Two studies were performed, with 40 male Wistar rats and with 40 Balb C male mice respectively.. In both studies, four groups received carrageenan and one control group received saline. At 1, 2, and 3 hours after injections, LLLT irradiation was performed with a dose of 7.5 J/cm². In the rat study, two of the carrageenan groups had the adrenal gland dissected. In the mice study, two of the carrageenan-injected groups were in addition pre-treated with orally administered mifepristone. Results: In the rat paw study, LLLT reduced edema significantly compared to the carrageenan only group (1.5 vs 0.9 ml, p< 0.05), but LLLT failed to inhibit edema formation in the group which had the adrenal gland resected. In carrageenan-induced pleurisy, LLLT significantly reduced the number of leukocyte cells ( p<0.0001, Mean 34.5 [95%CI: 32.8 - 36.2] versus 87.7 [95%CI: 81.0 - 94.4]), and that the effect of LLLT could be totally blocked by adding the cortisol antagonist mifepristone ( p<0.0001, Mean 34.5 [95%CI: 32.1 - 36.9] versus 82.9 [95%CI: 70.5 - 95.3]). Conclusion: Steroid therapy should not be used concomitantly with LLLT, as the anti-inflammatory effect of LLLT is lost if cortisol receptors are downregulated.

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Rodrigo Alvaro Brandao Lopes-Martins, Regiane Albertini, Patricia Sardinha Leonardo Lopes-Martins, Vegard Vereide Iversen, and Jan Magnus Bjordal "Steroids block the anti-inflammatory effects of low level laser therapy", Proc. SPIE 6140, Mechanisms for Low-Light Therapy, 61400D (28 February 2006); https://doi.org/10.1117/12.645468

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KEYWORDS

Therapeutics

Inflammation

Receptors

Laser therapeutics

Modulation

Statistical analysis

Laser irradiation

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