Influence of laser light on AMPK as a factor in the laser therapy of diabetes

A. M. Makela M.D.

doi:10.1117/12.645879

28 February 2006 Influence of laser light on AMPK as a factor in the laser therapy of diabetes

A. M. Makela M.D.

Proceedings Volume 6140, Mechanisms for Low-Light Therapy; 61400N (2006) https://doi.org/10.1117/12.645879
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The use of light and laser in the treatment of diabetes has been under research and some controversy. The following paper explores some of the mechanisms involved in glucose level regulation in connection to light. Several researchers have found that laser irradiation can activate ATP production, influence redox values within cells, and have other effects which can (in)directly activate AMP-activated protein kinase (AMPK). The activation of AMPK plays an important, albeit not an exclusive, role in the induction of GLUT4 recruitment to the plasma membrane. In addition, there is some demonstration that AMPK may regulate glucose transport through GLUT1. Increased glucose uptake will result in an increase in glycolysis and ATP production.

Citation Download Citation

A. M. Makela M.D. "Influence of laser light on AMPK as a factor in the laser therapy of diabetes", Proc. SPIE 6140, Mechanisms for Low-Light Therapy, 61400N (28 February 2006); https://doi.org/10.1117/12.645879

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