Mechanisms of in vivo optical clearing of human skin at application of glycerol and lattice-like photothermal damage of stratum corneum

Anna A. Gavrilova; Alexander B. Pravdin; Elena A. Zubkova; Valery V. Tuchin; Gregory B. Altshuler; Ilya V. Yaroslavsky

doi:10.1117/12.697340

24 July 2006 Mechanisms of in vivo optical clearing of human skin at application of glycerol and lattice-like photothermal damage of stratum corneum

Anna A. Gavrilova, Alexander B. Pravdin, Elena A. Zubkova, Valery V. Tuchin, Gregory B. Altshuler, Ilya V. Yaroslavsky

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Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 61631E (2006) https://doi.org/10.1117/12.697340
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

Controlling of optical properties of skin is of great interest for skin diseases monitoring and phototherapy. Glycerol, as the most effective optical clearing agent, was applied in this study. Effects of osmotic properties of glycerol on optical clearing of the human skin have been investigated. Two main mechanisms of optical clearing at a creation of lattice-like pattern of localized thermal damage islets in the SC, glycerol diffusion into damaged skin and tissue dehydration, were discussed.

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Anna A. Gavrilova, Alexander B. Pravdin, Elena A. Zubkova, Valery V. Tuchin, Gregory B. Altshuler, and Ilya V. Yaroslavsky "Mechanisms of in vivo optical clearing of human skin at application of glycerol and lattice-like photothermal damage of stratum corneum", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61631E (24 July 2006); https://doi.org/10.1117/12.697340

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