Blood porphyrin luminescence and tumor growth correlation

Lilia Coronato Courrol; Flávia Rodrigues de Oliveira Silva; Maria Helena Bellini; Ronaldo Domingues Mansano; Nestor Schor; Nilson Dias Vieira Jr.

doi:10.1117/12.698366

6 March 2007 Blood porphyrin luminescence and tumor growth correlation

Lilia Coronato Courrol, Flávia Rodrigues de Oliveira Silva, Maria Helena Bellini, Ronaldo Domingues Mansano, Nestor Schor, Nilson Dias Vieira Jr.

Author Affiliations +

Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 64270Y (2007) https://doi.org/10.1117/12.698366
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Fluorescence technique appears very important for the diagnosis of cancer. Fluorescence detection has advantages over other light-based investigation methods: high sensitivity, high speed, and safety. Renal cell carcinoma (RCC) accounts for approximately 3% of new cancer incidence and mortality in the United States. Unfortunately many RCC masses remain asymptomatic and nonpalpable until they are advanced. Diagnosis and localization of early carcinoma play an important role in the prevention and curative treatment of RCC. Certain drugs or chemicals such as porphyrin derivatives accumulate substantially more in tumors than normal tissues. The autofluorescence of blood porphyrin of healthy and tumor induced male SCID mice was analyzed using fluorescence and excitation spectroscopy. A significant contrast between normal and tumor blood could be established. Blood porphyrin fluorophore showed enhanced fluorescence band (around 630 nm) in function of the tumor growth. This indicates that either the autofluorescence intensity of the blood fluorescence may provide a good parameter for the "first approximation" characterization of the tumor stage.

Citation Download Citation

Lilia Coronato Courrol, Flávia Rodrigues de Oliveira Silva, Maria Helena Bellini, Ronaldo Domingues Mansano, Nestor Schor, and Nilson Dias Vieira Jr. "Blood porphyrin luminescence and tumor growth correlation", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64270Y (6 March 2007); https://doi.org/10.1117/12.698366

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