Breast cancer detection using phase-contrast diffuse optical tomography

Xiaoping Liang; Qizhi Zhang; Changqing Li; Stephen R. Grobmyer; Laurie L. Fajardo; Huabei Jiang

doi:10.1117/12.700279

13 February 2007 Breast cancer detection using phase contrast diffuse optical tomography

Xiaoping Liang, Qizhi Zhang, Changqing Li, Stephen R. Grobmyer, Laurie L. Fajardo, Huabei Jiang

Proceedings Volume 6434, Optical Tomography and Spectroscopy of Tissue VII; 643425 (2007) https://doi.org/10.1117/12.700279
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

In this report, a phase-contrast diffuse optical tomography system, which can measure the refractive indices of human breast masses in vivo, is described. To investigate the utility of phase-contrast diffuse optical tomography (PCDOT) for differentiation of malignant and benign breast masses in humans, and to compare PCDOT with conventional diffuse optical tomography (DOT) for analysis of breast masses in humans. 35 breast masses were imaged in 33 patients (mean age = 51 years; range 22-80 years) using PCDOT. Images characterizing the tissue refractive index, absorption and scattering of breast masses were obtained with a finite element-based reconstruction algorithm. The accuracies of absorption and scattering images were compared with images of refractive index in light of the pathology results. Absorption and scattering images were unable to accurately discriminate benign from malignant lesions. Malignant lesions tended to have decreased refractive index allowing them to discriminate from benign lesions in most cases. The sensitivity, specificity, false positive value, and overall accuracy for refractive index were 81.8%, 70.8%, 29.2%, and 74.3%, respectively. Overall we show that benign and malignant breast masses in humans demonstrate different refractive index and differences in refractive index properties can be used to discriminate benign from malignant masses in patients with high accuracy. This opens up a new avenue for improved breast cancer detection using NIR diffusing light.

Citation Download Citation

Xiaoping Liang, Qizhi Zhang, Changqing Li, Stephen R. Grobmyer, Laurie L. Fajardo, and Huabei Jiang "Breast cancer detection using phase contrast diffuse optical tomography", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 643425 (13 February 2007); https://doi.org/10.1117/12.700279

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available