Sergey Ermilov,1 Alan Stein,2 Andre Conjusteau,1 Reda Gharieb,1 Ron Lacewell,1 Tom Miller,1 Scott Thompson,2 Pamela Otto,3 Barbara McCorvey,3 Tuenchit Khamapirad,4 Morton Leonard,4 Alexander Oraevsky1
1Fairway Medical Technologies (United States) 2Seno Medical Instruments (United States) 3The Univ. of Texas Health Science Ctr. at San Antonio (United States) 4The Univ. of Texas Medical Branch at Galveston (United States)
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We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative
optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of
the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used
to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio
objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small
(less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured
that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly
for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the
low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms
mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images
obtained at 1064 nm and 757 nm.
Sergey Ermilov,Alan Stein,Andre Conjusteau,Reda Gharieb,Ron Lacewell,Tom Miller,Scott Thompson,Pamela Otto,Barbara McCorvey,Tuenchit Khamapirad,Morton Leonard, andAlexander Oraevsky
"Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643703 (15 February 2007); https://doi.org/10.1117/12.714039
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Sergey Ermilov, Alan Stein, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Scott Thompson, Pamela Otto, Barbara McCorvey, Tuenchit Khamapirad, Morton Leonard, Alexander Oraevsky, "Detection and noninvasive diagnostics of breast cancer with 2-color laser optoacoustic imaging system," Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643703 (15 February 2007); https://doi.org/10.1117/12.714039