NAOMI: nanoparticle-assisted optical molecular imaging

Dirk J. Faber; Martijn de Bruin; Maurice C. G. Aalders; Frank D. Verbraak; Ton G. van Leeuwen

doi:10.1117/12.701262

12 February 2007 NAOMI: nanoparticle-assisted optical molecular imaging

Dirk J. Faber, Martijn de Bruin, Maurice C. G. Aalders, Frank D. Verbraak, Ton G. van Leeuwen

Proceedings Volume 6447, Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV; 64470I (2007) https://doi.org/10.1117/12.701262
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We present our first steps towards nanoparticle assisted, optical molecular imaging (NAOMI) using biodegradable nanoparticles. Our focus is on using optical coherence tomography(OCT) as the imaging modality. We propose to use nanoparticles based on biodegradable polymers, loaded with carefully selected dyes as contrast agent, and outline a method for establishing their desired optical properties prior to synthesis. Moreover, we perform a qualitative pilot study using these biodegradable nanoparticles, measuring their optical properties which are found to be in line with theoretical predictions.

Citation Download Citation

Dirk J. Faber, Martijn de Bruin, Maurice C. G. Aalders, Frank D. Verbraak, and Ton G. van Leeuwen "NAOMI: nanoparticle-assisted optical molecular imaging", Proc. SPIE 6447, Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for Biomedical Applications IV, 64470I (12 February 2007); https://doi.org/10.1117/12.701262

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