Automated Chromosome Analysis: A State-Of-The-Art Approach To Knowledge Based Image Analysis

J Jaschul

doi:10.1117/12.938292

17 November 1986 Automated Chromosome Analysis: A State-Of-The-Art Approach To Knowledge Based Image Analysis

J Jaschul

Proceedings Volume 0654, Automatic Optical Inspection; (1986) https://doi.org/10.1117/12.938292
Event: 1986 International Symposium/Innsbruck, 1986, Innsbruck, Austria

Abstract

This paper describes a completely automated chromosome analysis system. It comprises of an automated microscope, an image analysis system for evaluation of the microscopic fields, and peripheral equipment for user dialogue and control of the procedures. Photo-quality hard copies of the completed karyograms are output via a special printer. Metaphases are found fully automatically by the system. A research quality microscope is used for automatic screening of up to 16 slides in one metaphase finding run. The metaphase finding is based on a special cluster analysis. By resetting the metaphase models, the system can be adapted to different staining techniques. Metaphase coordinates are stored in the system enabling automatic repositioning under high magnification. The system can be used for counting the chromosomes of all metaphases as well as for karyotyping, based on banding analysis. The karyotyping algorithm is based on classification of the banding pattern of each chromosome. The knowledge base is derived from a banding pattern analysis of 4000 chromosomes.

Citation Download Citation

J Jaschul "Automated Chromosome Analysis: A State-Of-The-Art Approach To Knowledge Based Image Analysis", Proc. SPIE 0654, Automatic Optical Inspection, (17 November 1986); https://doi.org/10.1117/12.938292

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