Real-time monitoring system for microfluidics

F. Sapuppo; G. Cantelli; L. Fortuna; P. Arena; M. Bucolo

doi:10.1117/12.721902

22 May 2007 Real-time monitoring system for microfluidics

F. Sapuppo, G. Cantelli, L. Fortuna, P. Arena, M. Bucolo

Proceedings Volume 6592, Bioengineered and Bioinspired Systems III; 65920Q (2007) https://doi.org/10.1117/12.721902
Event: Microtechnologies for the New Millennium, 2007, Maspalomas, Gran Canaria, Spain

Abstract

A new non-invasive real-time system for the monitoring and control of microfluidodynamic phenomena is proposed. The general purpose design of such system is suitable for in vitro and in vivo experimental setup and therefore for microfluidic application in the biomedical field such as lab-on-chip and for research studies in the field of microcirculation. The system consists of an ad hoc optical setup for image magnification providing images suitable for image acquisition and processing. The optic system was designed and developed using discrete opto-mechanic components mounted on a breadboard in order to provide an optic path accessible at any point where the information needs to be acquired. The optic sensing, acquisition, and processing were performed using an integrated vision system based on the Cellular Nonlinear Networks (CNNs) analogic technology called Focal Plane Processor (FPP, Eye-RIS, Anafocus) and inserted in the optic path. Ad hoc algorithms were implemented for the real-time analysis and extraction of fluido-dynamic parameters in micro-channels. They were tested on images recorded during in vivo microcirculation experiments on hamsters and then they were applied on images optically acquired and processed in real-time during in vitro experiments on a continuous microfluidic device (serpentine mixer, ThinXXS) with a two-phase fluid.

Citation Download Citation

F. Sapuppo, G. Cantelli, L. Fortuna, P. Arena, and M. Bucolo "Real-time monitoring system for microfluidics", Proc. SPIE 6592, Bioengineered and Bioinspired Systems III, 65920Q (22 May 2007); https://doi.org/10.1117/12.721902

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