Determination of the optical properties of vascular tissues: potential applications in vascular-targeting photodynamic therapy

Yongbin Tian; Ping Chen; Lie Lin; Zheng Huang; Guoqing Tang; Heping Xu

doi:10.1117/12.758255

18 January 2008 Determination of the optical properties of vascular tissues: potential applications in vascular-targeting photodynamic therapy

Yongbin Tian, Ping Chen, Lie Lin, Zheng Huang, Guoqing Tang, Heping Xu

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Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 68261Q (2008) https://doi.org/10.1117/12.758255
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

It has been proven that photodynamic therapy (PDT) is effective in treating various malignant and non-malignant diseases. In the treatment of certain non-malignant vascular diseases, such as wet age-related macular degeneration (AMD) and port wine stains (PWS), unlike in the treatment of malignant solid tumors, light irradiation usually starts immediately after the intravenous (IV) injection of photosensitizers while the photosensitizers is mainly circulating inside blood vessels. Under such vascular-targeting action mode, photoreactions between photosensitizers and light can selectively destruct the vascular tissues. Light distribution is complex so that it is important to understand the optical properties of targeted vessels and surrounding tissues. To better determine the optical properties of vascular tissues, we developed a tissue-simulating phantom and adopted frequency-domain measurement of phase difference. Absorption and reduced scattering coefficients in blood vessels were estimated and light distribution was simulated by the Monte Carlo method. These determinations are essential for the implication of better light dosimetry models in clinical photodynamic therapy and vascular-targeting PDT, in particular.

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Yongbin Tian, Ping Chen, Lie Lin, Zheng Huang, Guoqing Tang, and Heping Xu "Determination of the optical properties of vascular tissues: potential applications in vascular-targeting photodynamic therapy", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261Q (18 January 2008); https://doi.org/10.1117/12.758255

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KEYWORDS

Tissues

Photodynamic therapy

Optical properties

Monte Carlo methods

Absorption

Scattering

Light scattering

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