Frequency encoded assessment of retinal physiology

Rainer A. Leitgeb; Roland Michaely; Adrian Bachmann; Theo Lassner; Cedric Blatter

doi:10.1117/12.764330

25 February 2008 Frequency encoded optical assessment of human retinal physiology

Rainer A. Leitgeb, Roland Michaely, Adrian Bachmann, Theo Lassner, Cedric Blatter

Proceedings Volume 6844, Ophthalmic Technologies XVIII; 68440I (2008) https://doi.org/10.1117/12.764330
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We demonstrate in-vivo functional imaging of the human retina with Fourier domain optical coherence tomography employing frequency encoding of an excitation pattern. The principle is based on projecting a modulated rectangular pattern across the foveal region and acquiring a time series of B-Scans at the same vertical position across the pattern. The idea is to modulate the excitation with a frequency that is distinct from the heartbeat and irregular motion artifacts. Fourier analysis of the time series at each transverse position in the B-scan series allows assessing the retinal response as change in the FDOCT reflectivity signal exactly at the pattern modulation frequency. We observe a change in retinal reflectivity within the region of the outer segment photoreceptor layer exactly at the pattern modulation frequency.

Citation Download Citation

Rainer A. Leitgeb, Roland Michaely, Adrian Bachmann, Theo Lassner, and Cedric Blatter "Frequency encoded optical assessment of human retinal physiology", Proc. SPIE 6844, Ophthalmic Technologies XVIII, 68440I (25 February 2008); https://doi.org/10.1117/12.764330

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