Imaging of artificial cartilage with optical coherence tomography

K. Eder; R. Schmitt; R. Müller-Rath

doi:10.1117/12.762810

6 February 2008 Imaging of artificial cartilage with optical coherence tomography

K. Eder, R. Schmitt, R. Müller-Rath

Proceedings Volume 6858, Optics in Tissue Engineering and Regenerative Medicine II; 68580J (2008) https://doi.org/10.1117/12.762810
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Tissue Engineering methods have become more and more relevant for orthopedic applications, especially for cartilage repair with autologous chondrocytes. In order to monitor the healing process and bonding between cartilage and the artificial implant, the boundary zone must be imaged non-invasively, for example with OCT. Optical Coherence Tomography (OCT) is a short coherent light based measuring technique which allows the generation of cross-section images of semi-transparent media with a depth resolution of up to 5 μm and a measuring depth of 1-2 mm. Especially for the imaging of cartilage OCT offers new diagnostic possibilities, as conventional methods such as ultrasound and x-ray imaging often do not yield satisfactory resolution or contrast. In this paper, an OCT measurement setup for imaging of human cartilage tissue with OCT is demonstrated, allowing a detection of local damaging and lesions. Furthermore, both compressed and uncompressed collagen gel pads were implanted into human cartilage samples. OCT measurements are presented for samples in different stages of growth, focusing on the boundary zones. Comparisons with histologies are shown, demonstrating the ability of OCT to enable a monitoring of the healing progress in tissue engineering based therapy.

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K. Eder, R. Schmitt, and R. Müller-Rath "Imaging of artificial cartilage with optical coherence tomography", Proc. SPIE 6858, Optics in Tissue Engineering and Regenerative Medicine II, 68580J (6 February 2008); https://doi.org/10.1117/12.762810

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KEYWORDS

Cartilage

Optical coherence tomography

Collagen

Tissues

In vivo imaging

Image resolution

Tissue engineering

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