Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

Amy L. Oldenburg; Matthew N. Hansen; Alexander Wei; Stephen A. Boppart M.D.

doi:10.1117/12.761886

22 February 2008 Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei, Stephen A. Boppart M.D.

Proceedings Volume 6867, Molecular Probes for Biomedical Applications II; 68670E (2008) https://doi.org/10.1117/12.761886
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Plasmon-resonant gold nanorods have been demonstrated recently as contrast agents for optical coherence tomography (OCT). To evaluate their ability to produce contrast in a structurally heterogeneous environment, nanorods were injected at discrete locations into an excised sample of human breast invasive ductal carcinoma. The distribution of nanorods within the tissue was revealed using spectroscopic OCT imaging techniques, by analyzing the evolution of the backscattered light spectrum over tissue depth. We compare a variety of signal processing methods including spatial averaging and least-squares fitting to the a priori extinction spectrum of the nanorods, with the goal of optimizing the detection sensitivity to the nanorods in these tissues. Because nanorods can be conjugated with proteins specific to biomolecular targets, they may potentially be used with these imaging methods to provide molecular contrast in human tissues.

Citation Download Citation

Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei, and Stephen A. Boppart M.D. "Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors", Proc. SPIE 6867, Molecular Probes for Biomedical Applications II, 68670E (22 February 2008); https://doi.org/10.1117/12.761886

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available