New efficient near-IR photosensitizer based on bacteriochlorin p N-methoxycycloimide oxyme methyl ester

Igor G. Meerovich; Mikhail A. Grin; Alexander G. Tsyprovskiy; Gennady A. Meerovich; Natalia A. Oborotova; Victor B. Loschenov II; Anatoly Yu. Baryshnikov; Andrey F. Mironov

doi:10.1117/12.803904

5 June 2008 New efficient near-IR photosensitizer based on bacteriochlorin p N-methoxycycloimide oxyme methyl ester

Igor G. Meerovich, Mikhail A. Grin, Alexander G. Tsyprovskiy, Gennady A. Meerovich, Natalia A. Oborotova, Victor B. Loschenov II, Anatoly Yu. Baryshnikov, Andrey F. Mironov

Author Affiliations +

Proceedings Volume 7022, Advanced Laser Technologies 2007; 702204 (2008) https://doi.org/10.1117/12.803904
Event: Advanced Laser Technologies 2007, 2007, Levi, Finland

Abstract

This work is devoted to investigation of new photosensitizer Bacteriochlorin p N-methoxycycloimide oxyme methyl ester (BchlpOx-NOMe). Investigations of photosensitizer in vivo and experimental PDT were performed on animals bearing intramuscularly inoculated Erlich tumor and B16 melanoma. Characteristic absorption maximum of BchlpOx-NOMe around 795 nm is within the range of minimum intrinsic absorption of biological tissue. Dynamics and selectivity of sensitizer accumulation in tumor and normal tissue were estimated from spectra of absorption of sensitized tissue in vivo. The investigation has shown that the optimum time range to start PDT irradiation of tumor is 10-30 min after administration. Photosensitizer has shown high photodynamic efficiency of relatively large tumors, including high PDT efficiency in preliminary experiments with BDF1 mice bearing B16 melanoma, causing tumor growth inhibition more than 90% and prolongation of lifespan of tumor-bearing animals more than 60%.

Citation Download Citation

Igor G. Meerovich, Mikhail A. Grin, Alexander G. Tsyprovskiy, Gennady A. Meerovich, Natalia A. Oborotova, Victor B. Loschenov II, Anatoly Yu. Baryshnikov, and Andrey F. Mironov "New efficient near-IR photosensitizer based on bacteriochlorin p N-methoxycycloimide oxyme methyl ester", Proc. SPIE 7022, Advanced Laser Technologies 2007, 702204 (5 June 2008); https://doi.org/10.1117/12.803904

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available