Fast 3-D photoacoustic imaging in vivo with a high frequency ultrasound array toward clinical applications

Liang Song; Konstantin Maslov; Rachel Bitton; K. Kirk Shung; Lihong V. Wang

doi:10.1117/12.809013

24 February 2009 Fast 3-D photoacoustic imaging in vivo with a high frequency ultrasound array toward clinical applications

Liang Song, Konstantin Maslov, Rachel Bitton, K. Kirk Shung, Lihong V. Wang

Author Affiliations +

Proceedings Volume 7177, Photons Plus Ultrasound: Imaging and Sensing 2009; 71770G (2009) https://doi.org/10.1117/12.809013
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We present an in vivo reflection-mode photoacoustic microscopy system that performs B-scan imaging at 50 Hz with realtime beamforming and 3-D imaging of 166 B-scan frames at 1 Hz with post-beamforming. To our knowledge, this speed is currently the fastest in high frequency photoacoustic imaging. In addition, with a custom fiber based light delivery system, the imaging device is capable of performing handheld operation. Software for image processing and display with clinically user-friendly graphic user interface (GUI) is developed. The system has axial, lateral, and elevational resolutions of 25, 70, and 200 μm, respectively, and can image 3 mm deep in scattering biological tissue. Volumetric images of subcutaneous vasculature in murine are demonstrated in vivo. The system is anticipated to have potential clinical applications in skin melanoma detection due to its unique ability to image in realtime and to image anatomical sites inaccessible to other imaging systems.

Citation Download Citation

Liang Song, Konstantin Maslov, Rachel Bitton, K. Kirk Shung, and Lihong V. Wang "Fast 3-D photoacoustic imaging in vivo with a high frequency ultrasound array toward clinical applications", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770G (24 February 2009); https://doi.org/10.1117/12.809013

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