Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer

Baowei Fei; Hesheng Wang; Chunying Wu; Joseph Meyers; Liang-Yan Xue; Gregory MacLennan; Mark Schluchter

doi:10.1117/12.812129

27 February 2009 Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer

Baowei Fei, Hesheng Wang, Chunying Wu, Joseph Meyers, Liang-Yan Xue, Gregory MacLennan, Mark Schluchter

Author Affiliations +

Proceedings Volume 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging; 726211 (2009) https://doi.org/10.1117/12.812129
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with ¹¹C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of ¹¹C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p ⪅ 0.001). However, for the control tumors, normalized choline uptake increased significantly (p ⪅ 0.001). PET imaging with ¹¹C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.

Citation Download Citation

Baowei Fei, Hesheng Wang, Chunying Wu, Joseph Meyers, Liang-Yan Xue, Gregory MacLennan, and Mark Schluchter "Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer", Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 726211 (27 February 2009); https://doi.org/10.1117/12.812129

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