An optogenetic neural stimulation platform for concurrent induction and recording of neural activity

Brian McGovern; Nir Grossman; Rolando Berlinguer-Palmini; Mark Neil; Emmanuel Drakakis; Patrick Degenaar

doi:10.1117/12.842665

2 March 2010 An optogenetic neural stimulation platform for concurrent induction and recording of neural activity

Brian McGovern, Nir Grossman, Rolando Berlinguer-Palmini, Mark Neil, Emmanuel Drakakis, Patrick Degenaar

Author Affiliations +

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75484X (2010) https://doi.org/10.1117/12.842665
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

The precise control of neural activity afforded by the use of light sensitive ion channels such as Channel Rhodopsin (ChR2) offers neuroscientists the means to devise new experiments. In this paper we present the Optogenetic Neural Stimulation (ONS) platform which enables complex in-vitro or ex-vivo investigation of neural activity. The platform is based on micro-meter sized Light Emitting Diodes (LEDs) integrated onto a single Gallium Nitrite chip. Mounted onto a microscope system, this system can be used to carry out experiments on networks of cells, or on sub-cellular regions of a neuron with millisecond timing and micrometer resolution.

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Brian McGovern, Nir Grossman, Rolando Berlinguer-Palmini, Mark Neil, Emmanuel Drakakis, and Patrick Degenaar "An optogenetic neural stimulation platform for concurrent induction and recording of neural activity", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484X (2 March 2010); https://doi.org/10.1117/12.842665

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