Enhanced PNA detection sensitivity based on polymer-cladded porous silicon waveguide

Yang Jiao; Sharon M. Weiss

doi:10.1117/12.842258

25 February 2010 Enhanced PNA detection sensitivity based on polymer-cladded porous silicon waveguide

Yang Jiao, Sharon M. Weiss

Proceedings Volume 7553, Frontiers in Pathogen Detection: From Nanosensors to Systems; 75530O (2010) https://doi.org/10.1117/12.842258
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

In this work, we theoretically and experimentally demonstrate a highly sensitive polymer-cladded porous silicon (PSi) membrane waveguide based on a ~1.55 μm thick porous silicon membrane coated on one side with a low loss polymer. The sensor operates in the Kretschmann configuration, which is amenable to microfluidics integration, with a high index cubic zirconium prism. The sensitivity of the sensor is investigated through PNA hybridization in the PSi membrane. We demonstrate that higher angle resonances and a proper ratio of PNA length to PSi pore diameter lead to significantly improved detection sensitivity. A detection sensitivity below 0.1°/μM is reported for 16mer target PNA. Calculations and complimentary experiments show that careful tuning of the polymer cladding thickness can further improve the detection performance.

Citation Download Citation

Yang Jiao and Sharon M. Weiss "Enhanced PNA detection sensitivity based on polymer-cladded porous silicon waveguide", Proc. SPIE 7553, Frontiers in Pathogen Detection: From Nanosensors to Systems, 75530O (25 February 2010); https://doi.org/10.1117/12.842258

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