Imaging hypoxia using 3D photoacoustic spectroscopy

Keith M. Stantz

doi:10.1117/12.842143

25 February 2010 Imaging hypoxia using 3D photoacoustic spectroscopy

Keith M. Stantz

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 756419 (2010) https://doi.org/10.1117/12.842143
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Purpose: The objective is to develop a multivariate in vivo hemodynamic model of tissue oxygenation (MiHMO₂) based on 3D photoacoustic spectroscopy. Introduction: Low oxygen levels, or hypoxia, deprives cancer cells of oxygen and confers resistance to irradiation, some chemotherapeutic drugs, and oxygen-dependent therapies (phototherapy) leading to treatment failure and poor disease-free and overall survival. For example, clinical studies of patients with breast carcinomas, cervical cancer, and head and neck carcinomas (HNC) are more likely to suffer local reoccurrence and metastasis if their tumors are hypoxic. A novel method to non invasively measure tumor hypoxia, identify its type, and monitor its heterogeneity is devised by measuring tumor hemodynamics, MiHMO₂. Material and Methods: Simulations are performed to compare tumor pO₂ levels and hypoxia based on physiology - perfusion, fractional plasma volume, fractional cellular volume - and its hemoglobin status - oxygen saturation and hemoglobin concentration - based on in vivo measurements of breast, prostate, and ovarian tumors. Simulations of MiHMO₂ are performed to assess the influence of scanner resolutions and different mathematic models of oxygen delivery. Results: Sensitivity of pO₂ and hypoxic fraction to photoacoustic scanner resolution and dependencies on model complexity will be presented using hemodynamic parameters for different tumors. Conclusions: Photoacoustic CT spectroscopy provides a unique ability to monitor hemodynamic and cellular physiology in tissue, which can be used to longitudinally monitor tumor oxygenation and its response to anti-angiogenic therapies.

Citation Download Citation

Keith M. Stantz "Imaging hypoxia using 3D photoacoustic spectroscopy", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756419 (25 February 2010); https://doi.org/10.1117/12.842143

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