A time-domain fluorescence diffusion optical tomography system for breast tumor diagnosis

Wei Zhang; Feng Gao; LinHui Wu; Wenjuan Ma; Fang Yang; Zhongxing Zhou; Limin Zhang; Huijuan Zhao

doi:10.1117/12.873367

1 March 2011 A time-domain fluorescence diffusion optical tomography system for breast tumor diagnosis

Wei Zhang, Feng Gao, LinHui Wu, Wenjuan Ma, Fang Yang, Zhongxing Zhou, Limin Zhang, Huijuan Zhao

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 789619 (2011) https://doi.org/10.1117/12.873367
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A prototype time-domain fluorescence diffusion optical tomography (FDOT) system using near-infrared light is presented. The system employs two pulsed light sources, 32 source fibers and 32 detection channels, working separately for acquiring the temporal distribution of the photon flux on the tissue surface. The light sources are provided by low power picosecond pulsed diode lasers at wavelengths of 780 nm and 830 nm, and a 1×32-fiber-optic-switch sequentially directs light sources to the object surface through 32 source fibers. The light signals re-emitted from the object are collected by 32 detection fibers connected to four 8×1 fiber-optic-switch and then routed to four time-resolved measuring channels, each of which consists of a collimator, a filter wheel, a photomultiplier tube (PMT) photon-counting head and a time-correlated single photon counting (TCSPC) channel. The performance and efficacy of the designed multi-channel PMT-TCSPC system are assessed by reconstructing the fluorescent yield and lifetime images of a solid phantom.

Citation Download Citation

Wei Zhang, Feng Gao, LinHui Wu, Wenjuan Ma, Fang Yang, Zhongxing Zhou, Limin Zhang, and Huijuan Zhao "A time-domain fluorescence diffusion optical tomography system for breast tumor diagnosis", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789619 (1 March 2011); https://doi.org/10.1117/12.873367

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KEYWORDS

Optical fibers

Calibration

Sensors

Optical tomography

Luminescence

Diffusion

Tumors

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