Oxygen consumption estimation with combined color doppler ultrasound and photoacoustic microscopy: a phantom study

Yan Jiang; Tyler Harrison; Alex Forbrich; Roger J. Zemp

doi:10.1117/12.875786

22 February 2011 Oxygen consumption estimation with combined color doppler ultrasound and photoacoustic microscopy: a phantom study

Yan Jiang, Tyler Harrison, Alex Forbrich, Roger J. Zemp

Author Affiliations +

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 789942 (2011) https://doi.org/10.1117/12.875786
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The metabolic rate of oxygen consumption (MRO₂) quantifies tissue metabolism, which is important for diagnosis of many diseases. For a single vessel model, the MRO₂ can be estimated in terms of the mean flow velocity, vessel crosssectional area, total concentration of hemoglobin (CHB), and the difference between the oxygen saturation (sO₂) of blood flowing into and out of the tissue region. In this work, we would like to show the feasibility to estimate MRO₂ with our combined photoacoustic and high-frequency ultrasound imaging system. This system uses a swept-scan 25-MHz ultrasound transducer with confocal dark-field laser illumination optics. A pulse-sequencer enables ultrasonic and laser pulses to be interlaced so that photoacoustic and Doppler ultrasound images are co-registered. Since the mean flow velocity can be measured by color Doppler ultrasound, the vessel cross-sectional area can be measured by power Doppler or photoacoustic imaging, and multi-wavelength photoacoustic methods can be used to estimate sO₂ and C_HB, all of these parameters necessary for MRO₂ estimation can be provided by our system. Experiments have been performed on flow phantoms to generate co-registered color Doppler and photoacoustic images. To verify the sO₂ estimation, two ink samples (red and blue) were mixed in various concentration ratios to mimic different levels of sO₂, and the result shows a good match between the calculated concentration ratios and actual values.

Citation Download Citation

Yan Jiang, Tyler Harrison, Alex Forbrich, and Roger J. Zemp "Oxygen consumption estimation with combined color doppler ultrasound and photoacoustic microscopy: a phantom study", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789942 (22 February 2011); https://doi.org/10.1117/12.875786

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