Synthesis and biological studies of highly concentrated lisinopril-capped gold nanoparticles for CT tracking of angiotensin converting enzyme (ACE)

William E. Ghann; Omer Aras; Thorsten Fleiter; Marie-Christine Daniel

doi:10.1117/12.885526

26 May 2011 Synthesis and biological studies of highly concentrated lisinopril-capped gold nanoparticles for CT tracking of angiotensin converting enzyme (ACE)

William E. Ghann, Omer Aras, Thorsten Fleiter, Marie-Christine Daniel

Author Affiliations +

Proceedings Volume 8025, Smart Biomedical and Physiological Sensor Technology VIII; 80250H (2011) https://doi.org/10.1117/12.885526
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

For patients with a history of heart attack or stroke, the prevention of another cardiovascular or cerebrovascular event is crucial. The development of cardiac and pulmonary fibrosis has been associated with overexpression of tissue angiotensin-converting enzyme (ACE). Recently, gold nanoparticles (GNPs) have shown great potential as X-ray computed tomography (CT) contrast agents. Since lisinopril is an ACE inhibitor, it has been used as coating on GNPs for targeted imaging of tissue ACE in prevention of fibrosis. Herein, lisinopril-capped gold nanoparticles (LIS-GNPs) were synthesized up to a concentration of 55 mgAu/mL. Their contrast was measured using CT and the results were compared to Omnipaque, a commonly used iodine-based contrast agent. The targeting ability of these LIS-GNPs was also assessed.

Citation Download Citation

William E. Ghann, Omer Aras, Thorsten Fleiter, and Marie-Christine Daniel "Synthesis and biological studies of highly concentrated lisinopril-capped gold nanoparticles for CT tracking of angiotensin converting enzyme (ACE)", Proc. SPIE 8025, Smart Biomedical and Physiological Sensor Technology VIII, 80250H (26 May 2011); https://doi.org/10.1117/12.885526

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