Effect of magnetic field in malaria diagnosis using magnetic nanoparticles

Quan Liu; Clement Yuen

doi:10.1117/12.889360

8 June 2011 Effect of magnetic field in malaria diagnosis using magnetic nanoparticles

Quan Liu, Clement Yuen

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 80870E (2011) https://doi.org/10.1117/12.889360
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

The current gold standard method of Malaria diagnosis relies on the blood smears examination. The method is laborintensive, time consuming and requires the expertise for data interpretation. In contrast, Raman scattering from a metabolic byproduct of the malaria parasite (Hemozoin) shows the possibility of rapid and objective diagnosis of malaria. However, hemozoin concentration is usually extremely low especially at the early stage of malaria infection, rendering weak Raman signal. In this work, we propose the sensitive detection of enriched β-hematin, whose spectroscopic properties are equivalent to hemozoin, based on surface enhanced Raman spectroscopy (SERS) by using magnetic nanoparticles. A few orders of magnitude enhancement in the Raman signal of β-hematin can be achieved using magnetic nanoparticles. Furthermore, the effect of magnetic field on SERS enhancement is investigated. Our result demonstrates the potential of SERS using magnetic nanoparticles in the effective detection of hemozoin for malaria diagnosis.

Citation Download Citation

Quan Liu and Clement Yuen "Effect of magnetic field in malaria diagnosis using magnetic nanoparticles", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80870E (8 June 2011); https://doi.org/10.1117/12.889360

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