Functional imaging of tumor vascular network in small animal models

Vyacheslav Kalchenko; Noa Madar-Balakirski; Yuri Kuznetsov; Igor Meglinski; Alon Harmelin

doi:10.1117/12.890746

9 June 2011 Functional imaging of tumor vascular network in small animal models

Vyacheslav Kalchenko, Noa Madar-Balakirski, Yuri Kuznetsov, Igor Meglinski, Alon Harmelin

Proceedings Volume 8090, Novel Biophotonic Techniques and Applications; 809007 (2011) https://doi.org/10.1117/12.890746
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

In current report we present synchronized in vivo imaging of tumor vascular network and tumor microenvironment obtained by combined use of Dynamic Light Scattering Imaging, Spectrally Enhanced Microscopy, and Fluorescence Intravital Microscopy. Dynamic Light Scattering Imaging is used for functional imaging of the vascular network and blood microcirculation. Spectrally Enhanced Microscopy provides information regarding blood vessel topography. Fluorescence Intravital Microscopy is used for imaging of tumor microvasculature and tumor microenvironment. These well known modalities have been comprehensively validated in the past and are widely used in various bio-medical applications. As shown here, their combined application has great potential for studies of vascular biology. This multi-modal non-invasive diagnostic technique expands our current capacity to investigate blood microcirculation and tumor angiogenesis in vivo, thereby contributing to the development of cancer research and treatment.

Citation Download Citation

Vyacheslav Kalchenko, Noa Madar-Balakirski, Yuri Kuznetsov, Igor Meglinski, and Alon Harmelin "Functional imaging of tumor vascular network in small animal models", Proc. SPIE 8090, Novel Biophotonic Techniques and Applications, 809007 (9 June 2011); https://doi.org/10.1117/12.890746

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available