Photoswitchable bactericidal effects from novel silica-coated silver nanoparticles

Gustavo Fuertes; Esteban Pedrueza; Kamal Abderrafi; Rafael Abargues; Orlando Sánchez; Juan Martínez-Pastor; Jesús Salgado; Ernesto Jiménez

doi:10.1117/12.889675

2 June 2011 Photoswitchable bactericidal effects from novel silica-coated silver nanoparticles

Gustavo Fuertes, Esteban Pedrueza, Kamal Abderrafi, Rafael Abargues, Orlando Sánchez, Juan Martínez-Pastor, Jesús Salgado, Ernesto Jiménez

Author Affiliations +

Proceedings Volume 8092, Medical Laser Applications and Laser-Tissue Interactions V; 80921M (2011) https://doi.org/10.1117/12.889675
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

The enhancement of the electromagnetic field in the surroundings of nanoparticles via surface plasmon resonance offers promising possibilities for biomedical applications. Here we report on the selective triggering of antibacterial activity using a new type of silver nanoparticles coated with silica, Ag@silica, irradiated at their surface plasmon frequency. The nanoparticles are able to bind readily to the surface of bacterial cells, although this does not affect bacterial growing since the silica shell largely attenuates the intrinsic toxicity of silver. However, upon simultaneous exposure to light corresponding to the absorption band of the nanoparticles, bacterial death is triggered selectively on the irradiated zone. Because of the low power density used in the treatments, we discard thermal effects as the cause of cell killing. Instead, we propose that the switched toxicity is due to the enhanced electromagnetic field in the proximity of the nanoparticles, which either directly (through membrane perturbation) or indirectly (through induced photochemical reactions) is able to cause cell death.

Citation Download Citation

Gustavo Fuertes, Esteban Pedrueza, Kamal Abderrafi, Rafael Abargues, Orlando Sánchez, Juan Martínez-Pastor, Jesús Salgado, and Ernesto Jiménez "Photoswitchable bactericidal effects from novel silica-coated silver nanoparticles", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80921M (2 June 2011); https://doi.org/10.1117/12.889675

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available