Towards spatial frequency domain optical imaging of neurovascular coupling in a mouse model of Alzheimer's disease

Alexander J. Lin; Soren D. Konecky; Tyler B. Rice; Kim N. Green; Bernard Choi; Anthony J. Durkin; Bruce J. Tromberg

doi:10.1117/12.907557

9 February 2012 Towards spatial frequency domain optical imaging of neurovascular coupling in a mouse model of Alzheimer's disease

Alexander J. Lin, Soren D. Konecky, Tyler B. Rice, Kim N. Green, Bernard Choi, Anthony J. Durkin, Bruce J. Tromberg

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Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82074U (2012) https://doi.org/10.1117/12.907557
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Early neurovascular coupling (NVC) changes in Alzheimer's disease can potentially provide imaging biomarkers to assist with diagnosis and treatment. Previous efforts to quantify NVC with intrinsic signal imaging have required assumptions of baseline optical pathlength to calculate changes in oxy- and deoxy-hemoglobin concentrations during evoked stimuli. In this work, we present an economical spatial frequency domain imaging (SFDI) platform utilizing a commercially available LED projector, camera, and off-the-shelf optical components suitable for imaging dynamic optical properties. The fast acquisition platform described in this work is validated on silicone phantoms and demonstrated in neuroimaging of a mouse model.

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Alexander J. Lin, Soren D. Konecky, Tyler B. Rice, Kim N. Green, Bernard Choi, Anthony J. Durkin, and Bruce J. Tromberg "Towards spatial frequency domain optical imaging of neurovascular coupling in a mouse model of Alzheimer's disease", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074U (9 February 2012); https://doi.org/10.1117/12.907557

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