A compact laparoscope type radiation source for the pin-point cancer treatment using a femtosecond laser

N. Kawashima; H. Muramatsu; M. Ueda; C. Yanagimoto; M. Miyazawa; E. Kajiwara

doi:10.1117/12.908249

9 March 2012 A compact laparoscope type radiation source for the pin-point cancer treatment using a femtosecond laser

N. Kawashima, H. Muramatsu, M. Ueda, C. Yanagimoto, M. Miyazawa, E. Kajiwara

Proceedings Volume 8210, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI; 82100N (2012) https://doi.org/10.1117/12.908249
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Focusing a femto-second laser (1 mJ/pulse repetition 1 kHz) on a special tape, a strong radiation consisting of the electron beam of ~ 200 keV and X-rays of ~ 6.4 keV (5 %) has been generated. It has been verified that the radiation source is sufficient to kill the tumor cells and the DNA laddering structure in the in-vivo test is obtained. More test implanting the tumor under the skin of mouse and irradiating the laser-generated radiation, we have shown the radiation has a clear powerful therapeutic capability. For about 80 % of mice irradiated, their tumor disappeared. For further clinical test use, a compact laparoscope-type unit mounted on an articulated arm has been constructed and it can generate the necessary amount of the radiation dose.

Citation Download Citation

N. Kawashima, H. Muramatsu, M. Ueda, C. Yanagimoto, M. Miyazawa, and E. Kajiwara "A compact laparoscope type radiation source for the pin-point cancer treatment using a femtosecond laser", Proc. SPIE 8210, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI, 82100N (9 March 2012); https://doi.org/10.1117/12.908249

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