Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

Vivek J. Srinivasan; Harsha Radhakrishnan; James Y. Jiang; Scott Barry; Alex E. Cable

doi:10.1117/12.911587

30 January 2012 Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast

Vivek J. Srinivasan, Harsha Radhakrishnan, James Y. Jiang, Scott Barry, Alex E. Cable

Proceedings Volume 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI; 82131Y (2012) https://doi.org/10.1117/12.911587
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.

Citation Download Citation

Vivek J. Srinivasan, Harsha Radhakrishnan, James Y. Jiang, Scott Barry, and Alex E. Cable "Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast", Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82131Y (30 January 2012); https://doi.org/10.1117/12.911587

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