An intraoperative probe combining positron detection and OCT imaging for ovarian cancer detection and characterization

Yi Yang; Tianheng Wang; Nrusingh Biswal; Patrick Kumavor; Xiaohong Wang; Mozafareddin Karimeddini; John Vento; Melinda Sanders; Molly Brewer; Quing Zhu

doi:10.1117/12.907023

1 February 2012 An intraoperative probe combining positron detection and OCT imaging for ovarian cancer detection and characterization

Yi Yang, Tianheng Wang, Nrusingh Biswal, Patrick Kumavor, Xiaohong Wang, Mozafareddin Karimeddini, John Vento, Melinda Sanders, Molly Brewer, Quing Zhu

Author Affiliations +

Proceedings Volume 8220, Optical Biopsy X; 82200E (2012) https://doi.org/10.1117/12.907023
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper, we report an intraoperative approach by combining optical coherence tomography (OCT) and position detection to detect and characterize ovarian cancers. A total of 18 ovaries were studied ex vivo. Based on histopathology result, they were classified into normal and malignant groups, respectively. On average positron count rate of 8.0-fold higher was found between malignant and normal ovaries. OCT imaging of ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in ovarian tissue. Optical scattering coefficients of these ovaries were estimated from OCT A-lines. Normal ovarian tissue showed higher scattering coefficient than that of malignant ovarian tissue. Using a threshold of 2.00 mm^-1 for all ovaries, a sensitivity of 100% and a specificity of 100% were achieved. This initial data shows our intraoperative probe based on OCT and positron detection has a great potential for ovarian cancer detection and characterization.

Citation Download Citation

Yi Yang, Tianheng Wang, Nrusingh Biswal, Patrick Kumavor, Xiaohong Wang, Mozafareddin Karimeddini, John Vento, Melinda Sanders, Molly Brewer, and Quing Zhu "An intraoperative probe combining positron detection and OCT imaging for ovarian cancer detection and characterization", Proc. SPIE 8220, Optical Biopsy X, 82200E (1 February 2012); https://doi.org/10.1117/12.907023

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