Fighting cancer with magnetic nanoparticles and immunotherapy

L. Gutiérrez; R. Mejías; D. F. Barber; S. Veintemillas-Verdaguer; C. J. Serna; F. J. Lázaro; M. P. Morales

doi:10.1117/12.905890

2 February 2012 Fighting cancer with magnetic nanoparticles and immunotherapy

L. Gutiérrez, R. Mejías, D. F. Barber, S. Veintemillas-Verdaguer, C. J. Serna, F. J. Lázaro, M. P. Morales

Proceedings Volume 8232, Colloidal Nanocrystals for Biomedical Applications VII; 82320X (2012) https://doi.org/10.1117/12.905890
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

IFN-γ-adsorbed DMSA-coated magnetite nanoparticles can be used as an efficient in vivo drug delivery system for tumor immunotherapy. Magnetic nanoparticles, with adsorbed interferon-γ, were targeted to the tumor site by application of an external magnetic field. A relevant therapeutic dosage of interferon in the tumor was detected and led to a notable reduction in tumor size. In general, only 10% of the total injected nanoparticles after multiple exposures were found in tissues by AC susceptibility measurements of the corresponding resected tissues. Magnetic nanoparticle biodistribution is affected by the application of an external magnetic field.

Citation Download Citation

L. Gutiérrez, R. Mejías, D. F. Barber, S. Veintemillas-Verdaguer, C. J. Serna, F. J. Lázaro, and M. P. Morales "Fighting cancer with magnetic nanoparticles and immunotherapy", Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320X (2 February 2012); https://doi.org/10.1117/12.905890

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