Multifunctional nanocarriers for biomedical applications

R. Bleul; R. Thiermann; K. Saatchi; U. O. Häfeli; M. Maskos

doi:10.1117/12.2008194

22 February 2013 Multifunctional nanocarriers for biomedical applications

R. Bleul, R. Thiermann, K. Saatchi, U. O. Häfeli, M. Maskos

Proceedings Volume 8595, Colloidal Nanocrystals for Biomedical Applications VIII; 85951N (2013) https://doi.org/10.1117/12.2008194
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Polymeric vesicles (Pluronic^® L-121) loaded with magnetic nanoparticles (MNP) and an anti-cancer drug (camptothecin) were prepared continuously in a micro mixing device. Characterization by TEM confirmed the successful incorporation of the MNP and DLS measurements showed a relatively narrow size distribution of the hybrid polymersomes. A very high drug loading of camptothecin (100 μg/ml in the polymersome formulation) was reached and a drug release study of loaded magnetic polymersomes has shown a sustained camptothecin release over several days. Carboxylation of Pluronic^® L-121 was performed and enabled a further surface functionalization with bombesin, a 14 amino acid peptide, which binds specifically to the GRPR (gastrin releasing peptide receptor). This receptor is often overexpressed in tumor cells (e.g., human prostate cancer cells) and therefore a suitable target for cancer treatment. An additional fluorescence label with Alexa Fluor^® 647 allow tracking of the polymersomes e.g., in cell experiments. Relaxivity measurements to evaluate the potential of magnetic polymersomes as MR contrast agent for in vivo imaging are in progress.

Citation Download Citation

R. Bleul, R. Thiermann, K. Saatchi, U. O. Häfeli, and M. Maskos "Multifunctional nanocarriers for biomedical applications", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85951N (22 February 2013); https://doi.org/10.1117/12.2008194

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available