Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry

Haniel Gabai; Maya Baranes-Zeevi; Meital Zilberman; Natan T. Shaked

doi:10.1117/12.2020485

23 May 2013 Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, Natan T. Shaked

Author Affiliations +

Proceedings Volume 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials; 879215 (2013) https://doi.org/10.1117/12.2020485
Event: SPIE Optical Metrology 2013, 2013, Munich, Germany

Abstract

We propose an off-axis interferometric imaging system as a simple and unique modality for continuous, non-contact and non-invasive wide-field imaging and characterization of drug release from its polymeric device used in biomedicine. In contrast to the current gold-standard methods in this field, usually based on chromatographic and spectroscopic techniques, our method requires no user intervention during the experiment, and only one test-tube is prepared. We experimentally demonstrate imaging and characterization of drug release from soy-based protein matrix, used as skin equivalent for wound dressing with controlled anesthetic, Bupivacaine drug release. Our preliminary results demonstrate the high potential of our method as a simple and low-cost modality for wide-field imaging and characterization of drug release from drug delivery devices.

Citation Download Citation

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, and Natan T. Shaked "Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry", Proc. SPIE 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, 879215 (23 May 2013); https://doi.org/10.1117/12.2020485

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